h�bbd``b`z$��X���A ����� �% V�u��� �(�^e � �`�@b:@�y!��H�d`bd`��I�gl� ` XP This Site is intended for U.S. healthcare professionals only. 0

In a clinical trial, half of the patients with metastatic colon or rectal cancer treated with LONSURF ® (trifluridine and tipiracil) tablets were still alive at 7.1 months and half of the patients who received placebo were still alive at 5.3 months. ((�ct�����"l_ia �|���r�I���=��L�Lg�L�Vs&3�p�0q��f0m\�u��*v�o�@�(��9~4B���`�u��f`��*�0 �� Pregnant women should not take it, and women should not become pregnant while taking it.Between 1 and 10% of people have skin and mucosa issues, like rashes and itchiness, or mouth sores, as well as Tipiracil prevents the degradation of trifluridine via thymidine phosphorylase (TP) when taken orally and also has antiangiogenic properties.By the late 1960s, Phase I and Phase II clinical trials of intravenous trifluridine alone initially proved to be disappointing.Researchers later found out that trifluridine, when taken orally, was broken down into the inactive metabolites 5-trifluoromethyluracil and 5-trifluoromethyl-2,4(1Trifluridine/tipiracil was approved by the U.S. FDA in September 2015, Products discussed herein may have different labeling in different countries. Trifluridine and Tipiracil (Lonsurf®) Is an oral tablet available in 15 mg trifluridine/6.14 mg tipiracil and 20 mg trifluridine/8.19 mg tipiracil Take with food (1 hour after a meal), with a large glass of water at the same times each day *Treatment arms were LONSURF plus best supportive care vs placebo plus best supportive care.LONSURF is indicated for the treatment of adult patients with metastatic colorectal cancer previously treated with fluoropyrimidine‑, oxaliplatin‑ and irinotecan‑based chemotherapy, an anti‑VEGF biological therapy, and if LONSURF is indicated for the treatment of adult patients with metastatic gastric or gastroesophageal junction adenocarcinoma previously treated with at least two prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, LONSURF is indicated for the treatment of adult patients with metastatic colorectal cancer previously treated with fluoropyrimidine‑, oxaliplatin‑ and irinotecan‑based chemotherapy, an anti‑VEGF biological therapy, and if LONSURF is indicated for the treatment of adult patients with metastatic gastric or gastroesophageal junction adenocarcinoma previously treated with at least two prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, Pulmonary emboli occurred more frequently in LONSURF‑treated patients compared to placebo: in mCRC (2% vs 0%) and in metastatic gastric cancer and GEJ (3% vs 2%). For more information, ask your healthcare provider. LONSURF ® (trifluridine and tipiracil) tablets consist of a thymidine‑based nucleoside analog, trifluridine, and the thymidine phosphorylase inhibitor, tipiracil, at a molar ratio 1:0.5 (weight ratio, 1:0.471).

Call your doctor for medical advice about side effects. Use of this Site is subject to the Internet Site Legal Notices and Disclaimers and Privacy Policy. Tell your doctor if you have nausea, vomiting, or diarrhea that is severe or that does not go away.These are not all of the possible side effects of LONSURF. Patients were randomized 2:1 to receive either LONSURF 35 mg/m Call your doctor for medical advice about side effects.LONSURF is a prescription medicine used to treat adults withIt is not known if LONSURF is safe and effective in childrenTell your healthcare provider right away if you get any of the following signs and symptoms of infection during treatment with LONSURF: fever, chills, or body aches. products or services offered by the site. Behandeling met Lonsurf moet worden voorgeschreven door een arts die ervaring heeft met het gebruik van geneesmiddelen tegen kanker. This medicine is used when the cancer has spread to other parts of the body (metastatic).. Tipiracil and trifluridine is usually given after other treatments have failed. endstream endobj startxref Trifluridine/tipiracil is a combination drug that is used as a third- or fourth-line treatment of metastatic colorectal cancer, after chemotherapy and targeted therapeutics have failed.